Ep. 12 - Bioengineering Lungs w/ Dr. Joan Nichols

Dr. Joan Nichols's team at University of Texas Medical Branch has a mission - nobody's done it before, but they see no reason we shouldn't be trying to do it now: Bioengineering lungs from natural scaffolds. Joan's team recently completed a pilot study that successfully implanted bioengineered, lab-grown lungs into pigs, marking a huge milestone in the progression toward a future where transplant patients can receive organs specifically bioengineered and grown in a lab to be compatible with their bodies.

The Switch on Patreon: https://www.patreon.com/switch_podcast


UTMB Wonders-Could we grow lungs in a lab: https://www.utmbwonders.com/lungs-in-lab

TedX Talk: https://www.youtube.com/watch?v=eyHVlU1dNoE

CBS innovation Nation: https://www.youtube.com/watch?v=Y-tcMPfEwSM and https://www.thehenryford.org/explore/innovation-nation/episodes/lung-growing/


Science Translational Medicine: http://stm.sciencemag.org/content/10/452/eaao3926  


Current and past publications leading to the recent manuscript published in Science Translational Medicine:

1.      Nichols JE, S. LaFrancesca, JA Niles, SP Vega, LB Argueta, L. Frank, DC Christiani, R Pyles, B Hynes, R Zhang, A Miller, J Sakamoto, J Jessica Rhudy, G Hendricks, F Begarani,  X Liu, G Vargas, R Pal, I Patrikeev, L Woodson, A  Wacher,  M Grimaldo, D Weaver, R  Mlcak, J Cortiella The Next Step in the Production of Bioengineered Lungs for Clinical Application: Transplantation of Bioengineered Lung into a Large Animal Model. Science Translational Medicine, Accepted for publication June 2018.

2.      Fernandez-Moure JS, Van Eps JL, Rhudy JR, Cabrera J, Acharya GS, Tasciotti E, Sakamotos, Nichols JE. Porcine acellular lung matrix for wound healing and abdominal wall reconstruction: a pilot study. Tissue Engineering and Regenerative Medicine, 2016, vol7; p1-8.  

3.      Nichols JE, ,LaFrancesca S, Vega SP, Niles JA, Argueta LB, Riddle M, Sakamoto J, Vargas G, Pal R, Woodson L, Seanor D, Campbell G, Schnadig V, Rhudy J, Cortiella J New Life for Old Lungs “Whole Human Lung Bioengineering: Production and Assessment of a Bioengineered Pediatric Lung” Journal of Tissue Engineering and Regenerative Medicine e-published, January, 2016.

4.      Nichols J.E., Niles JA, Vega, SP, Arguetsa LB, Eastaway A and Cortiella J Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use. Exp Biol Med (Maywood). 2014 Sep;239(9):1135-69.

5.      Nichols JE, Niles JA, Vega SP, Cortiella J.Novel in vitro respiratory models to study lung development, physiology, pathology and toxicology.  Stem Cell Res Ther. 2013;4 Suppl 1:S7.. Epub 2013 Dec 20

6.      Melo E, Garreta E, Luque T, Cortiella J, Nichols J, Navajas D, Farré R. Effects of the Decellularization Method on the Local Stiffness of Acellular Lungs.Tissue Eng Part C Methods. 2013 Nov 6.

7.      Nichols JE, Niles J, Riddle M, Vargas G, Schilagard T, Ma L, Edward K, Lafrancesca S, Sakamoto J, Vega S, Ogedegbe M, Mlcak R, Deyo D, Woodson L, McQuitty C, Lick S, Beckles D, Melo E, Cortiella J. Production and Assessment of Decellularized Pig and Human Lung Scaffolds.Tissue Eng Part A. 2013 May 2.

8.      Nichols JE, Cortiella J, Lee J, Niles JA, Cuddihy M, Wang S, Bielitzki J, Cantu A, Mlcak R, Valdivia E, Yancy R, McClure ML, Kotov NA.In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry. Biomaterials. 2009 Feb;30(6):1071-9.

Ep. 11 - Entrepreneurship w/ Alleah Webb

Show Notes:

In this episode, we talk with Chase's cousin, Alleah Webb. Alleah is the CEO of Drifter Coffee, a successful mobile coffee truck in the greater Detroit area. We talk with Alleah about entrepreneurship, small-business ownership, and (of course) coffee.

The Switch on Patreon: https://www.patreon.com/switch_podcast

Drifter Coffee: http://driftercoffee.com/

Drifter on Instagram: http://instagram.com/driftercoffee

Drifter on Facebook: https://www.facebook.com/DriftercoffeeMI/

Drifter by Email: driftercoffee@gmail.com

Ep. 10 - Secular Buddhism w/ Noah Rasheta

Show Notes:

In this episode, we had the privilege of speaking with Noah Rasheta. Noah is the host of the Secular Buddhism podcast and the author of two books - Secular Buddhism and No-Nonsense Buddhism for Beginners. In this conversation, we talk about Noah's story and answer some of the basic, fundamental questions about Buddhist philosophy and practice.

The Switch on Patreon: https://www.patreon.com/switch_podcast

Noah's Instagram: http://instagram.com/noahrasheta

Secular Buddhism: https://secularbuddhism.com/


Ep. 09 - Curiosity w/ Christian Matyi

Show Notes:

In this episode, we talk with polymath Christian Matyi. Our conversation revolves around Christian's insight into how we try to explain ideas and find truths, as well as kindle curiosity and maintain epistemic humility.

The Switch on Patreon: https://www.patreon.com/switch_podcast

The Big Inside (Podcast): http://www.thebiginside.com/

Scorpio Creative: http://scorpiocreative.com/


Ep. 08 - Quantum Computing w/ John Azariah

Show Notes:

In this episode, we speak with John Azariah. John is a Principal Software Engineer at Microsoft Research Redmond, and a member of Microsoft Quantum. In this conversation we talk about Quantum Computers, what they can do, what quantum mechanics looks like from a practical perspective, and how Microsoft's approach to Quantum is different.

The Switch on Patreon: https://www.patreon.com/switch_podcast

Video referenced in intro: https://youtu.be/A9tKncAdlHQ


Microsoft Quantum: https://www.microsoft.com/en-us/quantum/default.aspx

MS Quantum on Twitter: https://twitter.com/MSFTQuantum/

John Azariah on Twitter: https://twitter.com/johnazariah/


Ep. 07 - Documentary Filmmaking w/ Matthew Podolski

Show Notes:

In this episode, Alex and Chase speak with Matthew Podolski. Matt is an Emmy-nominated filmmaker, conservationist, and co-founder of the company WildLens. In this conversation, we talk about the power of documentary filmmaking in changing public opinion, and the process of creating a compelling documentary. Matt was very generous with his time, and because of that we were able to have a long, engaging conversation.

The Switch on Patreon: https://www.patreon.com/switch_podcast

WildLens webite: http://www.wildlensinc.org/

WildLens on Twitter: @wildlensinc

WildLens on Facebook: WildLensInc

Episode photo credit: Tim Hauck

Ep. 06 - Art & Politics w/ Kate Dacey

Show Notes: 

In this episode we talk with Kate Dacey, musicologist, music historian, and associate professor at Berklee College of Music. The main theme of our discussion revolves around a single question: In the subjective world of art, can we find an objective way of talking about the ethics of consuming art. Is certain art unethical? Is it useful to boycott artists? How much should your aesthetic opinion be swayed by your opinion of the artist's politics or other factors?

The Switch on Patreon: https://www.patreon.com/switch_podcast

Ep. 05 - Free Speech w/ Daniel Miller

Show Notes: 

In this episode we speak with Daniel Miller about the constitution, free speech, and engagement in American politics. Danny is a lawyer and runs a civics group in New York City where he and others engage in discourse about the rights of American citizens, the history of those rights, and ways to fight encroachment and tyranny. 

The Switch on Patreon: https://www.patreon.com/switch_podcast

When I Lived There (Podcast): https://itunes.apple.com/us/podcast/when-i-lived-there/id1354078975?mt=2

Modern Patriotism (YouTube): https://www.youtube.com/channel/UC3t4pN9ZDraSblnQGDGwWHQ

The Society for Constitutional Protection (Meetup): http://meetu.ps/c/2WHwC/mHzQR/f